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Article

Genetic Variation in Targets of Antidiabetic Drugs and Alzheimer Disease Risk: A Mendelian Randomization Study.

Neurology - 16 Aug 2022

Tang Bowen, Wang Yunzhang, Jiang Xia, Thambisetty Madhav, Ferrucci Luigi, Johnell Kristina, Hägg Sara

Abstract excerpt

BACKGROUND AND OBJECTIVES: Previous studies have highlighted antidiabetic drugs as repurposing candidates for Alzheimer disease (AD), but the disease-modifying effects are still unclear. METHODS: A 2-sample mendelian randomization study design was applied to examine the association between genetic variation in the targets of 4 antidiabetic drug classes and AD risk. Genetic summary statistics for blood glucose...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35654594
DOI: 10.1212/WNL.0000000000200771
PMCID: PMC9484609

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