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Assessing the repurposing potential of disease-modifying antirheumatic drug targets to reduce Alzheimer’s disease risk: a pQTL-based Mendelian randomization and colocalization analysis

2025-08-06

Abstract excerpt

<h4>Background</h4> Current literature has implicated systemic inflammation in the pathogenesis of Alzheimer’s disease (AD). However, the viability of anti-inflammatory drug targets as repurposed treatment candidates for AD remains unclear. We utilized two-sample Mendelian randomization (MR) and colocalization analysis to investigate whether disease-modifying antirheumatic drug (DMARD) targets reduce AD risk. <h4...

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Literature Corpus work
bbd8c8bc-71a8-59dd-80a4-3b6eb7390403
DOI
10.1101/2025.08.01.25332834
Open publication

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Assessing the repurposing potential of disease-modifying antirheumatic drug targets to reduce Alzheimer’s disease risk: a pQTL-based Mendelian randomization and colocalization analysisDOI 10.1101/2025.08.01.25332834
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