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Article

Genome-wide analyses of multiple obesity-related cytokines and hormones informs biology of cardiometabolic traits.

Genome medicine - 7 Oct 2021

Meeks Karlijn A C, Bentley Amy R, Gouveia Mateus H, Chen Guanjie, Zhou Jie, Lei Lin, Adeyemo Adebowale A, Doumatey Ayo P, Rotimi Charles N

Abstract excerpt

BACKGROUND: A complex set of perturbations occur in cytokines and hormones in the etiopathogenesis of obesity and related cardiometabolic conditions such as type 2 diabetes (T2D). Evidence for the genetic regulation of these cytokines and hormones is limited, particularly in African-ancestry populations. In order to improve our understanding of the biology of cardiometabolic traits, we investigated the genetic...

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Identifiers

PMID: 34620218
DOI: 10.1186/s13073-021-00971-2
PMCID: PMC8499470

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