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Integrating informatics tools and portable sequencing technology for rapid detection of resistance to anti-tuberculous drugs

24 Jun 2019

Abstract excerpt

BACKGROUND: Mycobacterium tuberculosis resistance to anti-tuberculosis drugs is a major threat to global public health. Whole genome sequencing (WGS) is rapidly gaining traction as a diagnostic tool for clinical tuberculosis settings. To support this informatically, previous work led to the development of the widely used TBProfiler webtool, which predicts resistance to 14 drugs from WGS data. However, for...

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PMID: 31234910
DOI: 10.1186/s13073-019-0650-x

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