Article
Whole-genome sequencing reveals genotypic resistance in phenotypically susceptible Mycobacterium tuberculosis clinical isolates.
International journal of mycobacteriology - 1 Jan 2000
Hasan Zahra, Razzak Safina Abdul, Kanji Akbar, Shakoor Sadia, Hasan Rumina
Abstract excerpt
Background: Whole-genome sequencing (WGS) data of Mycobacterium tuberculosis (MTB) complex strains have revealed insights about genetic variants associated with drug resistance (DR). Rapid genome-based diagnostics are being sought for specific and sensitive identification of DR; however, correct prediction of resistance genotypes requires both informatics tools and understanding of available evidence. We analyzed...
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