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Machine Learning Predicts Accurately Mycobacterium tuberculosis Drug Resistance From Whole Genome Sequencing Data

26 Sept 2019

Abstract excerpt

Background: Tuberculosis disease, caused by Mycobacterium tuberculosis, is a major public health problem. The emergence of M. tuberculosis strains resistant to existing treatments threatens to derail control efforts. Resistance is mainly conferred by mutations in genes coding for drug-targets or -converting enzymes, but our knowledge of these mutations is incomplete. Whole genome sequencing (WGS) is an...

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PMID: 31616478
DOI: 10.3389/fgene.2019.00922

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