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Dissecting whole-genome sequencing-based online tools for predicting resistance in Mycobacterium tuberculosis: can we use them for clinical decision guidance?

Tuberculosis (Edinburgh, Scotland) - 1 May 2018

Macedo Rita, Nunes Alexandra, Portugal Isabel, Duarte Sílvia, Vieira Luís, Gomes João Paulo

Abstract excerpt

Whole-genome sequencing (WGS)-based bioinformatics platforms for the rapid prediction of resistance will soon be implemented in the Tuberculosis (TB) laboratory, but their accuracy assessment still needs to be strengthened. Here, we fully-sequenced a total of 54 multidrug-resistant (MDR) and five susceptible TB strains and performed, for the first time, a simultaneous evaluation of the major four free online...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29779772
DOI: 10.1016/j.tube.2018.03.009

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