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Article

TB-Genaly: A multicenter evaluated whole genome sequencing pipeline for tuberculosis drug resistance assessment and transmission analysis.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases - 1 Sept 2026

Ou Xichao, Pei Shaojun, Mao Lingfeng, Wu Hao, Zhao Bing, Wang Jichun, Xing Ruida, Xia Hui, Li Xue, Tan Yunhong, Wang Hui, Wang Chunhua, Zhang Shu, Guo Jingwei, Liu Xin, Wang Zhirui, He Jinge, Hou Ping, Zhao Yanlin

Abstract excerpt

OBJECTIVES: Whole-genome sequencing (WGS) enables comprehensive characterization of Mycobacterium tuberculosis (MTB), but its routine clinical use is limited by the lack of standardized and multicenter-validated analytical workflows. METHODS: We developed TB-Genaly, a user-friendly and secure bioinformatics pipeline for MTB WGS analysis. Performance of drug-resistance prediction was evaluated using a multicenter,...

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Antitubercular Agents
Computational Biology
Drug Resistance, Bacterial
Genome, Bacterial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mycobacterium tuberculosis

Sensitivity and Specificity

Tuberculosis, Multidrug-Resistant

Whole Genome Sequencing

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PMID: 42379459
DOI: 10.1016/j.ijid.2026.108942

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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