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Differential Impact of the rpoB Mutant on Rifampin and Rifabutin Resistance Signatures of Mycobacterium tuberculosis Is Revealed Using a Whole-Genome Sequencing Assay.

Microbiology spectrum - 31 Aug 2022

Yu Ming-Chih, Hung Ching-Sheng, Huang Chun-Kai, Wang Cheng-Hui, Liang Yu-Chih, Lin Jung-Chun

Abstract excerpt

Drug resistance in Mycobacterium tuberculosis (MTB) has long been a serious health issue worldwide. Most drug-resistant MTB isolates were identified due to treatment failure or in clinical examinations 3~6 months postinfection. In this study, we propose a whole-genome sequencing (WGS) pipeline via the Nanopore MinION platform to facilitate the efficacy of phenotypic identification of clinical isolates. We used...

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Identifiers

PMID: 35924839
DOI: 10.1128/spectrum.00754-22
PMCID: PMC9430608

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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