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Article

The variability and reproducibility of whole genome sequencing technology for detecting resistance to anti-tuberculous drugs

1 Dec 2016

Abstract excerpt

BACKGROUND: The emergence of resistance to anti-tuberculosis drugs is a serious and growing threat to public health. Next-generation sequencing is rapidly gaining traction as a diagnostic tool for investigating drug resistance in Mycobacterium tuberculosis to aid treatment decisions. However, there are few little data regarding the precision of such sequencing for assigning resistance profiles. METHODS: We...

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PMID: 28003022
DOI: 10.1186/s13073-016-0385-x

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