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Article

Testing tumors from different anatomic sites for clonal relatedness using somatic mutation data.

Biometrics - 1 Mar 2021

Ostrovnaya Irina, Mauguen Audrey, Seshan Venkatraman E, Begg Colin B

Abstract excerpt

A common task for the cancer pathologist is to determine, in a patient suffering from cancer, whether a new tumor in a distinct anatomic site from the primary is an independent occurrence of cancer or a metastasis. As mutational profiling of tumors becomes more widespread in routine clinical practice, this diagnostic task can be greatly enhanced by comparing mutational profiles of the tumors to determine if they...

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PMID: 32135575
DOI: 10.1111/biom.13256
PMCID: PMC8514156

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