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Article

The small GTPase RAB28 is required for phagocytosis of cone outer segments by the murine retinal pigmented epithelium

19 Sept 2018

Abstract excerpt

mice, whereas rod phagosomes displayed normal levels. A protein-protein interaction screen identified several RAB28-interacting proteins, including the prenyl-binding protein phosphodiesterase 6 δ-subunit (PDE6D) and voltage-gated potassium channel subfamily J member 13 (KCNJ13) present in the RPE apical processes. Of note, the loss of PDE6D prevented delivery of RAB28 to OSs. Taken together, these findings...

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PMID: 30228185
DOI: 10.1074/jbc.ra118.005484

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