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Article

Photoreceptor Disc Enclosure Is Tightly Controlled by Peripherin-2 Oligomerization.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 21 Apr 2021

Lewis Tylor R, Makia Mustafa S, Castillo Carson M, Al-Ubaidi Muayyad R, Naash Muna I, Arshavsky Vadim Y

Abstract excerpt

Mutations in the PRPH2 gene encoding the photoreceptor-specific protein PRPH2 (also known as peripherin-2 or rds) cause a broad range of autosomal dominant retinal diseases. Most of these mutations affect the structure of the light-sensitive photoreceptor outer segment, which is composed of a stack of flattened "disc" membranes surrounded by the plasma membrane. The outer segment is renewed on a daily basis in a...

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Source

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Identifiers

PMID: 33707293
DOI: 10.1523/JNEUROSCI.0041-21.2021
PMCID: PMC8055076

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Related research

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Photoreceptor Disc Enclosure Is Tightly Controlled by Peripherin-2 Oligomerization.PMID 33707293Read ↗

ROM1 is redundant to PRPH2 as a molecular building block of photoreceptor disc rims.Semantic proximity Read ↗

The Role of Peripherin-2/ROM1 Complexes in Photoreceptor Outer Segment Disc Morphogenesis.Semantic proximity Read ↗

The Interplay between Peripherin 2 Complex Formation and Degenerative Retinal Diseases.Semantic proximity Read ↗

Oligomerization of Prph2 and Rom1 is essential for photoreceptor outer segment formation.Semantic proximity Read ↗

A new mouse model for PRPH2 pattern dystrophy exhibits functional compensation prior and subsequent to retinal degeneration.Semantic proximity Read ↗

Prph2 initiates outer segment morphogenesis but maturation requires Prph2/Rom1 oligomerization.Semantic proximity Read ↗

PRPH2/RDS and ROM-1: Historical context, current views and future considerations.Semantic proximity Read ↗

Downregulation of rhodopsin is an effective therapeutic strategy in ameliorating peripherin-2-associated inherited retinal disorders.Semantic proximity Read ↗

Rom1 converts Y141C-Prph2-associated pattern dystrophy to retinitis pigmentosa.Semantic proximity Read ↗

ROM1 contributes to phenotypic heterogeneity in PRPH2-associated retinal disease.Semantic proximity Read ↗

The role of subunit assembly in peripherin-2 targeting to rod photoreceptor disk membranes and retinitis pigmentosa.Semantic proximity Read ↗

Prph2 disease mutations lead to structural and functional defects in the RPE.Semantic proximity Read ↗

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