Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transgelin is a TGFβ-inducible gene that regulates osteoblastic and adipogenic differentiation of human skeletal stem cells through actin cytoskeleston organization

4 Aug 2016

Abstract excerpt

Regenerative medicine is a novel approach for treating conditions in which enhanced bone regeneration is required. We identified transgelin (TAGLN), a transforming growth factor beta (TGFβ)-inducible gene, as an upregulated gene during in vitro osteoblastic and adipocytic differentiation of human bone marrow-derived stromal (skeletal) stem cells (hMSC). siRNA-mediated gene silencing of TAGLN impaired lineage...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Mesenchymal stem cell research
Share to Pluripotent Stem Cells Research
Share to TGF-β signaling in diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27490926
DOI: 10.1038/cddis.2016.196

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transgelin is a TGFβ-inducible gene that regulates osteoblastic and adipogenic differentiation of human skeletal stem cells through actin cytoskeleston organizationPMID 27490926Read ↗

Identification of Pathways Mediating Growth Differentiation Factor5-Induced Tenogenic Differentiation in Human Bone Marrow Stromal CellsSemantic proximity Read ↗

TGFβ1-Induced Differentiation of Human Bone Marrow-Derived MSCs Is Mediated by Changes to the Actin CytoskeletonSemantic proximity Read ↗

TGF-β-induced transgelin promotes bladder cancer metastasis by regulating epithelial-mesenchymal transition and invadopodia formationSemantic proximity Read ↗

Bioinformatics analysis of the biological changes involved in the osteogenic differentiation of human mesenchymal stem cellsSemantic proximity Read ↗

Targeting F-actin stress fibers to suppress the dedifferentiated phenotype in chondrocytes.Semantic proximity Read ↗

Nuclear Actin Polymerization Regulates Cell Epithelial‐Mesenchymal TransitionSemantic proximity Read ↗

Transcriptomic Profiling of Adipose Derived Stem Cells Undergoing Osteogenesis by RNA-SeqSemantic proximity Read ↗

Myoscaffolds reveal laminin scarring is detrimental for stem cell function while sarcospan induces compensatory fibrosisSemantic proximity Read ↗

Myofibroblast differentiation is governed by adhesion mechanics, and inhibition of Talin2 reverses lung and kidney fibrosisSemantic proximity Read ↗

Genetic programs of epithelial cell plasticity directed by transforming growth factor-βSemantic proximity Read ↗

Mutations in Fibronectin Dysregulate Chondrogenesis in Skeletal DysplasiaSemantic proximity Read ↗

Extracellular matrices of bone marrow stroma regulate cell phenotype and contribute to distinct stromal niches <i>in vivo</i>Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.