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Article

DNA Damage Follows Repair Factor Depletion and Portends Genome Variation in Cancer Cells after Pore Migration.

Current biology : CB - 23 Jan 2017

Irianto Jerome, Xia Yuntao, Pfeifer Charlotte R, Athirasala Avathamsa, Ji Jiazheng, Alvey Cory, Tewari Manu, Bennett Rachel R, Harding Shane M, Liu Andrea J, Greenberg Roger A, Discher Dennis E

Abstract excerpt

Migration through micron-size constrictions has been seen to rupture the nucleus, release nuclear-localized GFP, and cause localized accumulations of ectopic 53BP1-a DNA repair protein. Here, constricted migration of two human cancer cell types and primary mesenchymal stem cells (MSCs) increases DNA breaks throughout the nucleoplasm as assessed by endogenous damage markers and by electrophoretic "comet"...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27989676
DOI: 10.1016/j.cub.2016.11.049
PMCID: PMC5262636

Genes

GATA4
MSC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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