Article

Gaussian curvature dilutes the nuclear lamina, favoring nuclear rupture, especially at high strain rate

2021-10-15

Abstract excerpt

<h4>ABSTRACT</h4> Nuclear rupture has long been associated with deficits or defects in lamins, with recent results also indicating a role for actomyosin stress, but key physical determinants of rupture remain unclear. Here, lamin-B stably interacts with the nuclear membrane at sites of low Gaussian curvature yet dilutes at high-curvature to favor rupture, whereas lamin-A depletes similarly but only at high strain...

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Identifiers and source

Literature Corpus work: 9593009c-1979-5a2d-aed5-bcc8de2a32ae
DOI: 10.1101/2021.10.13.464257

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