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Western-style diet-induced microbial shifts and inflammation reprogram <i>c-Kit</i> ⁺ secretory cells into targets for tumor initiation

2026-04-09

Abstract excerpt

While colorectal cancer (CRC) is thought to originate primarily from resident stem cells, diet heavily influences intestinal stem cell homeostasis and disease onset. In this study, we demonstrate that a Western-style diet (WSD) alters intestinal homeostasis by uncoupling canonical stemness from tumorigenesis. WSD exposure suppresses canonical Lgr5 ⁺ stem cells while activating an alternative pool of facultative...

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Literature Corpus work
593b6504-79d9-5bb5-9e9c-cc27833934a0
DOI
10.64898/2026.04.06.716383
Open publication

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Western-style diet-induced microbial shifts and inflammation reprogram <i>c-Kit</i> ⁺ secretory cells into targets for tumor initiationDOI 10.64898/2026.04.06.716383
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