Article

Somatic mutation rates scale with lifespan across mammals

2021-08-19

Abstract excerpt

The rates and patterns of somatic mutation in normal tissues are largely unknown outside of humans. Comparative analyses can shed light on the diversity of mutagenesis across species and on long-standing hypotheses regarding the evolution of somatic mutation rates and their role in cancer and ageing. Here, we used whole-genome sequencing of 208 intestinal crypts from 56 individuals to study the landscape of somati...

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Literature Corpus work: 41319c3d-c44b-5f33-acbd-db662e6af9a1
DOI: 10.1101/2021.08.19.456982

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