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Article

Diverse MR1-restricted T cells in mice and humans

21 May 2019

Abstract excerpt

Abstract Mucosal-associated invariant T (MAIT) cells express an invariant TRAV1/TRAJ33 TCR-α chain and are restricted to the MHC-I-like molecule, MR1. Whether MAIT cell development depends on this invariant TCR-α chain is unclear. Here we generate Traj33 -deficient mice and show that they are highly depleted of MAIT cells; however, a residual population remains and can respond to exogenous antigen in vitro or...

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Identifiers

PMID: 31113973
DOI: 10.1038/s41467-019-10198-w

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