Article
Mucosal-associated invariant T cell-rich congenic mouse strain allows functional evaluation.
The Journal of clinical investigation - 2 Nov 2015
Cui Yue, Franciszkiewicz Katarzyna, Mburu Yvonne K, Mondot Stanislas, Le Bourhis Lionel, Premel Virginie, Martin Emmanuel, Kachaner Alexandra, Duban Livine, Ingersoll Molly A, Rabot Sylvie, Jaubert Jean, De Villartay Jean-Pierre, Soudais Claire, Lantz Olivier
Abstract excerpt
Mucosal-associated invariant T cells (MAITs) have potent antimicrobial activity and are abundant in humans (5%-10% in blood). Despite strong evolutionary conservation of the invariant TCR-α chain and restricting molecule MR1, this population is rare in laboratory mouse strains (≈0.1% in lymphoid organs), and lack of an appropriate mouse model has hampered the study of MAIT biology. Herein, we show that MAITs are...
Topics
- Animals
- Chemotaxis, Leukocyte
- Crosses, Genetic
- Disease Models, Animal
- Female
- Gene Rearrangement, alpha-Chain T-Cell Antigen Receptor
- Germ-Free Life
- Histocompatibility Antigens Class I
- Humans