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Article

Kappa chain maturation helps drive rapid development of an infant HIV-1 broadly neutralizing antibody lineage

16 May 2019

Abstract excerpt

HIV-infected infants develop broadly neutralizing plasma responses with more rapid kinetics than adults, suggesting the ontogeny of infant responses could better inform a path to achievable vaccine targets. Here we reconstruct the developmental lineage of BF520.1, an infant-derived HIV-specific broadly neutralizing antibody (bnAb), using computational methods developed specifically for this purpose. We find that...

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PMID: 31097697
DOI: 10.1038/s41467-019-09481-7

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