Article
Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus.
Nature - 25 Apr 2013
Liao Hua-Xin, Lynch Rebecca, Zhou Tongqing, Gao Feng, Alam S Munir, Boyd Scott D, Fire Andrew Z, Roskin Krishna M, Schramm Chaim A, Zhang Zhenhai, Zhu Jiang, Shapiro Lawrence, Mullikin James C, Gnanakaran S, Hraber Peter, Wiehe Kevin, Kelsoe Garnett, Yang Guang, Xia Shi-Mao, Montefiori David C, Parks Robert, Lloyd Krissey E, Scearce Richard M, Soderberg Kelly A, Cohen Myron, Kamanga Gift, Louder Mark K, Tran Lillian M, Chen Yue, Cai Fangping, Chen Sheri, Moquin Stephanie, Du Xiulian, Joyce M Gordon, Srivatsan Sanjay, Zhang Baoshan, Zheng Anqi, Shaw George M, Hahn Beatrice H, Kepler Thomas B, Korber Bette T M, Kwong Peter D, Mascola John R, Haynes Barton F
Abstract excerpt
Current human immunodeficiency virus-1 (HIV-1) vaccines elicit strain-specific neutralizing antibodies. However, cross-reactive neutralizing antibodies arise in approximately 20% of HIV-1-infected individuals, and details of their generation could provide a blueprint for effective vaccination. Here we report the isolation, evolution and structure of a broadly neutralizing antibody from an African donor followed...
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