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Article

Interferon-Stimulated Genes: What Do They All Do?

8 Jul 2019

Abstract excerpt

In the absence of an intact interferon (IFN) response, mammals may be susceptible to lethal viral infection. IFNs are secreted cytokines that activate a signal transduction cascade leading to the induction of hundreds of interferon-stimulated genes (ISGs). Remarkably, approximately 10% of the genes in the human genome have the potential to be regulated by IFNs. What do all of these genes do? It is a complex...

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PMID: 31283436
DOI: 10.1146/annurev-virology-092818-015756

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