Article
Brain Oxygen Extraction by Using MRI in Older Individuals: Relationship to Apolipoprotein E Genotype and Amyloid Burden.
Radiology - 1 Jul 2019
Lin Zixuan, Sur Sandeepa, Soldan Anja, Pettigrew Corinne, Miller Michael, Oishi Kenichi, Bilgel Murat, Moghekar Abhay, Pillai Jay J, Albert Marilyn, Lu Hanzhang
Abstract excerpt
Background Apolipoprotein E4 (APOE4) is a major genetic risk factor for late-onset Alzheimer disease. However, the mechanisms by which APOE4 affects the brain, underpinning this risk, have not been fully elucidated. Purpose To investigate the influence of APOE4 on global cerebral oxygen extraction fraction (OEF) and possible mediation through amyloid burden by using MRI-based brain oxygen extraction technique....
Read the complete abstract on PubMedTopics
- Aged
- Amyloid beta-Peptides
- Apolipoprotein E4
- Brain
- Female
- Genotype