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Article

Reduced cerebrovascular reactivity in young adults carrying the APOE ε4 allele.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Jun 2015

Suri Sana, Mackay Clare E, Kelly Michael E, Germuska Michael, Tunbridge Elizabeth M, Frisoni Giovanni B, Matthews Paul M, Ebmeier Klaus P, Bulte Daniel P, Filippini Nicola

Abstract excerpt

BACKGROUND: Functional magnetic resonance imaging (MRI) studies have shown that APOE ε2- and ε4-carriers have similar patterns of blood-oxygenation-level-dependent (BOLD) activation suggesting that we need to look beyond the BOLD signal to link APOE's effect on the brain to Alzheimer's disease (AD)-risk. METHODS: We evaluated APOE-related differences in BOLD activation in response to a memory task,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25160043
DOI: 10.1016/j.jalz.2014.05.1755

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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