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Article

APOE Genotype Modifies the Association of Fusiform Gyrus Cerebral Metabolic Rate of Oxygen Consumption and Object Naming Performance.

Journal of Alzheimer's disease : JAD - 1 Jan 2023

Hays Weeks Chelsea C, Zlatar Zvinka Z, Meloy M J, Shin David D, Thomas Liu, Wierenga Christina E

Abstract excerpt

BACKGROUND: The apolipoprotein E (APOE) ɛ4 allele confers risk for age and Alzheimer's disease related cognitive decline but the mechanistic link remains poorly understood. Blood oxygenation level dependent (BOLD) response in the fusiform gyrus (FG) during object naming appears greater among APOEɛ4 carriers even in the face of equivalent cognitive performance, suggesting neural compensation. However, BOLD is...

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Identifiers

PMID: 36641668
DOI: 10.3233/JAD-220749

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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