Lower cerebral oxygen utilization is associated with Alzheimer's disease-related neurodegeneration and poorer cognitive performance among apolipoprotein E ε4 carriers.

doi:10.1177/0271678X211056393

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Article

Lower cerebral oxygen utilization is associated with Alzheimer's disease-related neurodegeneration and poorer cognitive performance among apolipoprotein E ε4 carriers.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism - 1 Apr 2022

Robb W Hudson, Khan Omair A, Ahmed Humza A, Li Judy, Moore Elizabeth E, Cambronero Francis E, Pechman Kimberly R, Liu Dandan, Gifford Katherine A, Landman Bennett A, Donahue Manus J, Hohman Timothy J, Jefferson Angela L

Abstract excerpt

Oxygen extraction fraction (OEF) and cerebral metabolic rate of oxygen (CMRO2) are markers of cerebral oxygen homeostasis and metabolism that may offer insights into abnormal changes in brain aging. The present study cross-sectionally related OEF and CMRO2 to cognitive performance and structural neuroimaging variables among older adults (n = 246, 74 ± 7 years, 37% female) and tested whether apolipoprotein E...

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PMID: 34743630
DOI: 10.1177/0271678X211056393
PMCID: PMC9051148

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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