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Disentangling molecular alterations from water-content changes in the aging human brain using quantitative MRI

30 Jul 2019

Abstract excerpt

It is an open question whether aging-related changes throughout the brain are driven by a common factor or result from several distinct molecular mechanisms. Quantitative magnetic resonance imaging (qMRI) provides biophysical parametric measurements allowing for non-invasive mapping of the aging human brain. However, qMRI measurements change in response to both molecular composition and water content. Here, we...

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PMID: 31363094
DOI: 10.1038/s41467-019-11319-1

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