Telomerase reverse transcriptase ameliorates lung fibrosis by protecting alveolar epithelial cells against senescence

Abstract excerpt

Mutations in the genes encoding telomerase reverse transcriptase (TERT) and telomerase's RNA components as well as shortened telomeres are risk factors for idiopathic pulmonary fibrosis, where repetitive injury to the alveolar epithelium is considered a key factor in pathogenesis. Given the importance of TERT in stem cells, we hypothesized that TERT plays an important role in epithelial repair and that its...

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• Share to Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
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• Share to Telomeres, Telomerase, and Senescence