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Article

Telomerase treatment prevents lung profibrotic pathologies associated with physiological aging

10 Aug 2020

Abstract excerpt

Short/dysfunctional telomeres are at the origin of idiopathic pulmonary fibrosis (IPF) in patients mutant for telomere maintenance genes. However, it remains unknown whether physiological aging leads to short telomeres in the lung, thus leading to IPF with aging. Here, we find that physiological aging in wild-type mice leads to telomere shortening and a reduced proliferative potential of alveolar type II cells...

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Share to Occupational and environmental lung diseases
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Identifiers

PMID: 32777016
DOI: 10.1083/jcb.202002120

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