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Article

Therapeutic effects of telomerase in mice with pulmonary fibrosis induced by damage to the lungs and short telomeres

24 Jan 2018

Abstract excerpt

Pulmonary fibrosis is a fatal lung disease characterized by fibrotic foci and inflammatory infiltrates. Short telomeres can impair tissue regeneration and are found both in hereditary and sporadic cases. We show here that telomerase expression using AAV9 vectors shows therapeutic effects in a mouse model of pulmonary fibrosis owing to a low-dose bleomycin insult and short telomeres. AAV9 preferentially targets...

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Share to Congenital Anomalies and Fetal Surgery
Share to Telomeres, Telomerase, and Senescence
Share to Tissue Engineering and Regenerative Medicine

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PMID: 29378675
DOI: 10.7554/elife.31299

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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