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Consequences of telomere dysfunction in fibroblasts, club and basal cells for lung fibrosis development

6 Oct 2022

Abstract excerpt

TRF1 is an essential component of the telomeric protective complex or shelterin. We previously showed that dysfunctional telomeres in alveolar type II (ATII) cells lead to interstitial lung fibrosis. Here, we study the lung pathologies upon telomere dysfunction in fibroblasts, club and basal cells. TRF1 deficiency in lung fibroblasts, club and basal cells induced telomeric damage, proliferative defects, cell...

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PMID: 36202783
DOI: 10.1038/s41467-022-32771-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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