Article

Cellular profiling identifies an early profibrotic alveolar type 2 cell signature in lung fibrosis

2025-05-23

Abstract excerpt

<h4>Rationale</h4> Idiopathic pulmonary fibrosis (IPF) is a progressive, age-associated, lung disease characterized by short telomeres in alveolar type 2 (AT2) cells, epithelial remodeling, and fibrosis. <h4>Objectives</h4> This study investigated how telomere dysfunction in AT2 cells lacking Telomere Repeat Binding Factor 1 (TRF1) drives lung remodeling in SPC-creTRF1 flox/flox mice and its relevance to IPF....

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: db856d59-875f-5fc5-88e7-b837acf9a1d0
DOI: 10.1101/2025.05.22.655638

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cellular profiling identifies an early profibrotic alveolar type 2 cell signature in lung fibrosisDOI 10.1101/2025.05.22.655638Read

Telomere dysfunction in alveolar epithelial cells causes lung remodeling and fibrosisSemantic proximity Read

Senescence of alveolar stem cells drives progressive pulmonary fibrosisSemantic proximity Read

Autocrine TGF-β-positive feedback in profibrotic AT2-lineage cells plays a crucial role in non-inflammatory lung fibrogenesisSemantic proximity Read

Telomere shortening and DNA damage in culprit cells of different types of progressive fibrosing interstitial lung diseaseSemantic proximity Read

A transcriptional cell atlas identifies the decline in the AT2 niche in aged human lungsSemantic proximity Read

Single-cell RNA-seq reveals ectopic and aberrant lung-resident cell populations in idiopathic pulmonary fibrosisSemantic proximity Read

Consequences of telomere dysfunction in fibroblasts, club and basal cells for lung fibrosis developmentSemantic proximity Read

Single Cell Transcriptomics of Fibrotic Lungs Unveils Aging-associated Alterations in Endothelial and Epithelial Cell RegenerationSemantic proximity Read

Syndecan-1 Promotes Alveolar Type 2 Epithelial Cell Senescence during Lung FibrosisSemantic proximity Read

Transcriptomics Analysis Identifies the Decline in the Alveolar Type II Stem Cell Niche in Aged Human LungsSemantic proximity Read

Alveolar Epithelial Cell Loss of the Mitochondrial Regulator TFAM Drives Progressive Lung FibrosisSemantic proximity Read

Mice with Pulmonary Fibrosis Driven by Telomere DysfunctionSemantic proximity Read