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Article

Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis.

Nature reviews. Cancer - 1 Mar 2006

Cully Megan, You Han, Levine Arnold J, Mak Tak W

Abstract excerpt

The tumour-suppressor phosphatase with tensin homology (PTEN) is the most important negative regulator of the cell-survival signalling pathway initiated by phosphatidylinositol 3-kinase (PI3K). Although PTEN is mutated or deleted in many tumours, deregulation of the PI3K-PTEN network also occurs...

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Source

Identifiers

PMID: 16453012
DOI: 10.1038/nrc1819

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16453012-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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