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Article

PI3K/PTEN signaling in tumorigenesis and angiogenesis.

Biochimica et biophysica acta - 1 Jan 2008

Jiang Bing-Hua, Liu Ling-Zhi

Abstract excerpt

The phosphatidyl inositol 3-kinase (PI3K) can be activated by a variety of extracellular signals and involved in a number of cellular processes including cell proliferation, survival, protein synthesis, and tumor growth. Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) is an antagonist of PI3K. The alterations of PI3K pathway such as activation of oncogenes, gene amplification, and inactivation of...

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Share to Oncogenes
Share to Intercellular Signaling Peptides and Proteins
Share to Neovascularization, Pathologic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phosphatidylinositol 3-Kinases

Share to Phosphoinositide-3 Kinase Inhibitors

Share to Proto-Oncogene Proteins c-akt

Share to PTEN Phosphohydrolase

Share to TOR Serine-Threonine Kinases

Source

Identifiers

PMID: 17964232
DOI: 10.1016/j.bbapap.2007.09.008

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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