Decoding PTEN: from biological functions to signaling pathways in tumors.

Abstract excerpt

The tumor suppressor gene Phosphatase and tensin homologue deleted on chromosome 10 (PTEN), possessing both protein and lipid phosphatase activities, is frequently mutated in various human cancers. PTEN aberrations disrupt critical cellular processes like proliferation, apoptosis, migration, and invasion, thereby promoting tumor growth. In the cells, PTEN localizes to the nucleus, cytoplasm, or cell membrane, and...

Topics

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• Carcinogenesis
• Gene Expression Regulation, Neoplastic
• Mutation
• Neoplasms
• Protein Processing, Post-Translational