Article
PTEN and the PI3-kinase pathway in cancer.
Annual review of pathology - 1 Jan 2009
Chalhoub Nader, Baker Suzanne J
Abstract excerpt
PI3-kinase and PTEN are major positive and negative regulators, respectively, of the PI3-kinase pathway, which regulates growth, survival, and proliferation. These key signaling components are two of the most frequently mutated proteins in human cancers, resulting in unregulated activation of PI3K signaling and providing irrefutable genetic evidence of the central role of this pathway in tumorigenesis. PTEN...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.