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Single-cell RNA-seq variant analysis for exploration of genetic heterogeneity in cancer

2 Jul 2019

Abstract excerpt

Inter- and intra-tumour heterogeneity is caused by genetic and non-genetic factors, leading to severe clinical implications. High-throughput sequencing technologies provide unprecedented tools to analyse DNA and RNA in single cells and explore both genetic heterogeneity and phenotypic variation between cells in tissues and tumours. Simultaneous analysis of both DNA and RNA in the same cell is, however, still in...

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PMID: 31267007
DOI: 10.1038/s41598-019-45934-1

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