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Unravelling subclonal heterogeneity and aggressive disease states in TNBC through single-cell RNA-seq

29 Aug 2018

Abstract excerpt

Triple-negative breast cancer (TNBC) is an aggressive subtype characterized by extensive intratumoral heterogeneity. To investigate the underlying biology, we conducted single-cell RNA-sequencing (scRNA-seq) of >1500 cells from six primary TNBC. Here, we show that intercellular heterogeneity of gene expression programs within each tumor is variable and largely correlates with clonality of inferred genomic copy...

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PMID: 30181541
DOI: 10.1038/s41467-018-06052-0

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