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Article

Human MxA is a potent interspecies barrier for the novel bat-derived influenza A-like virus H18N11

1 Jan 2019

Abstract excerpt

The human innate immune factor MxA represents an effective interspecies barrier for zoonotic influenza A viruses (IAVs) of animal origin. Accordingly, human but not avian IAVs efficiently escape the antiviral activity of MxA due to adaptive mutations in their viral nucleoprotein. Partial MxA resistance can be acquired in intermediate hosts such as swine, which possess an antivirally active Mx1 protein....

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Identifiers

PMID: 30945621
DOI: 10.1080/22221751.2019.1599301

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