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Article

Mx genes: host determinants controlling influenza virus infection and trans-species transmission.

Human genetics - 1 Jun 2020

Haller Otto, Kochs Georg

Abstract excerpt

The human MxA protein, encoded by the interferon-inducible MX1 gene, is an intracellular influenza A virus (IAV) restriction factor. It can protect transgenic mice from severe IAV-induced disease, indicating a key role of human MxA for host survival and suggesting that natural variations in MX1 may account for inter-individual differences in disease severity among humans. MxA also provides a robust barrier...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31773252
DOI: 10.1007/s00439-019-02092-8
PMCID: PMC7087808

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