Article
In vivo evasion of MxA by avian influenza viruses requires human signature in the viral nucleoprotein.
The Journal of experimental medicine - 1 May 2017
Deeg Christoph M, Hassan Ebrahim, Mutz Pascal, Rheinemann Lara, Götz Veronika, Magar Linda, Schilling Mirjam, Kallfass Carsten, Nürnberger Cindy, Soubies Sébastien, Kochs Georg, Haller Otto, Schwemmle Martin, Staeheli Peter
Abstract excerpt
Zoonotic transmission of influenza A viruses can give rise to devastating pandemics, but currently it is impossible to predict the pandemic potential of circulating avian influenza viruses. Here, we describe a new mouse model suitable for such risk assessment, based on the observation that the innate restriction factor MxA represents an effective species barrier that must be overcome by zoonotic viruses. Our...
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