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Article

Increased Polymerase Activity of Zoonotic H7N9 Allows Partial Escape from MxA.

Viruses - 24 Oct 2022

Petric Philipp P, King Jacqueline, Graf Laura, Pohlmann Anne, Beer Martin, Schwemmle Martin

Abstract excerpt

The interferon-induced myxovirus resistance protein A (MxA) is a potent restriction factor that prevents zoonotic infection from influenza A virus (IAV) subtype H7N9. Individuals expressing antivirally inactive MxA variants are highly susceptible to these infections. However, human-adapted IAVs have acquired specific mutations in the viral nucleoprotein (NP) that allow escape from MxA-mediated restriction but...

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Identifiers

PMID: 36366429
DOI: 10.3390/v14112331
PMCID: PMC9695009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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