Article
Influenza A viruses escape from MxA restriction at the expense of efficient nuclear vRNP import.
Scientific reports - 18 Mar 2016
Götz Veronika, Magar Linda, Dornfeld Dominik, Giese Sebastian, Pohlmann Anne, Höper Dirk, Kong Byung-Whi, Jans David A, Beer Martin, Haller Otto, Schwemmle Martin
Abstract excerpt
To establish a new lineage in the human population, avian influenza A viruses (AIV) must overcome the intracellular restriction factor MxA. Partial escape from MxA restriction can be achieved when the viral nucleoprotein (NP) acquires the critical human-adaptive amino acid residues 100I/V, 283P, and 313Y. Here, we show that introduction of these three residues into the NP of an avian H5N1 virus renders it...
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