Article
Rare variant MX1 alleles increase human susceptibility to zoonotic H7N9 influenza virus.
Science (New York, N.Y.) - 20 Aug 2021
Chen Yongkun, Graf Laura, Chen Tao, Liao Qijun, Bai Tian, Petric Philipp P, Zhu Wenfei, Yang Lei, Dong Jie, Lu Jian, Chen Ying, Shen Juan, Haller Otto, Staeheli Peter, Kochs Georg, Wang Dayan, Schwemmle Martin, Shu Yuelong
Abstract excerpt
Zoonotic avian influenza A virus (IAV) infections are rare. Sustained transmission of these IAVs between humans has not been observed, suggesting a role for host genes. We used whole-genome sequencing to compare avian IAV H7N9 patients with healthy controls and observed a strong association between H7N9 infection and rare, heterozygous single-nucleotide variants in the MX1 gene. MX1 codes for myxovirus resistance...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.