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Mx1 Gene Protects Mice Against the Highly Lethal Human H5N1 Influenza Virus

1 Oct 2007

Abstract excerpt

We investigated the importance of the host Mx1 gene in protection against highly pathogenic H5N1 avian influenza virus. Mice expressing the Mx1 gene survived infection with the lethal human H5N1 isolate A/Vietnam/1203/04 and with reassortants combining its genes with those of the non-lethal virus A/chicken/Vietnam/C58/04, while all Mx1-/- mice succumbed. Mx1-expressing mice showed lower organ virus titers, fewer...

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PMID: 17700072
DOI: 10.4161/cc.6.19.4779

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