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Article

Abnormal oxidative metabolism in a quiet genomic background underlies clear cell papillary renal cell carcinoma

29 Mar 2019

Abstract excerpt

While genomic sequencing routinely identifies oncogenic alterations for the majority of cancers, many tumors harbor no discernable driver lesion. Here, we describe the exceptional molecular phenotype of a genomically quiet kidney tumor, clear cell papillary renal cell carcinoma (CCPAP). In spite of a largely wild-type nuclear genome, CCPAP tumors exhibit severe depletion of mitochondrial DNA (mtDNA) and RNA and...

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PMID: 30924768
DOI: 10.7554/elife.38986

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