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Article

Decreased Mitochondrial DNA Content Drives OXPHOS Dysregulation in Chromophobe Renal Cell Carcinoma.

Cancer research - 15 Sept 2020

Xiao Yi, Clima Rosanna, Busch Jonas, Rabien Anja, Kilic Ergin, Villegas Sonia L, Timmermann Bernd, Attimonelli Marcella, Jung Klaus, Meierhofer David

Abstract excerpt

Chromophobe renal cell carcinoma (chRCC) and renal oncocytoma are closely related, rare kidney tumors. Mutations in complex I (CI)-encoding genes play an important role in dysfunction of the oxidative phosphorylation (OXPHOS) system in renal oncocytoma, but are less frequently observed in chRCC. As such, the relevance of OXPHOS status and role of CI mutations in chRCC remain unknown. To address this issue, we...

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PMID: 32694149
DOI: 10.1158/0008-5472.CAN-20-0754

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