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Article

Mechanical Activation of Hypoxia-Inducible Factor 1α Drives Endothelial Dysfunction at Atheroprone Sites.

Arteriosclerosis, thrombosis, and vascular biology - 1 Nov 2017

Feng Shuang, Bowden Neil, Fragiadaki Maria, Souilhol Celine, Hsiao Sarah, Mahmoud Marwa, Allen Scott, Pirri Daniela, Ayllon Blanca Tardajos, Akhtar Shamima, Thompson A A Roger, Jo Hanjoong, Weber Christian, Ridger Victoria, Schober Andreas, Evans Paul C

Abstract excerpt

OBJECTIVE: Atherosclerosis develops near branches and bends of arteries that are exposed to low shear stress (mechanical drag). These sites are characterized by excessive endothelial cell (EC) proliferation and inflammation that promote lesion initiation. The transcription factor HIF1α (hypoxia-inducible factor 1α) is canonically activated by hypoxia and has a role in plaque neovascularization. We studied the...

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Source

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Identifiers

PMID: 28882872
DOI: 10.1161/ATVBAHA.117.309249
PMCID: PMC5659306

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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