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Article

The role of platelet-endothelial cell adhesion molecule-1 in atheroma formation varies depending on the site-specific hemodynamic environment.

Arteriosclerosis, thrombosis, and vascular biology - 1 Apr 2013

Harrison Matthew, Smith Emily, Ross Ewan, Krams Robert, Segers Dolf, Buckley Christopher D, Nash Gerard B, Rainger G Ed

Abstract excerpt

OBJECTIVE: Polymorphisms in the platelet-endothelial cell adhesion molecule (PECAM-1)-1 gene are linked to increased risk of coronary artery disease. Because PECAM-1 has been demonstrated to form a mechanosensory complex that can modulate inflammatory responses in murine arterial endothelial cells, we hypothesized that PECAM-1 contributes to atherogenesis in a shear-dependent and site-specific manner. APPROACH...

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Source

Identifiers

PMID: 23372062
DOI: 10.1161/ATVBAHA.112.300379

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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